Cyclic Neutropenia


Cyclic neutropenia is a rare congenital (since birth) blood disorder characterized by abnormally low levels of certain white cells (neutrophils) in the blood. It presents itself with recurrent infections in the body like repetitive episodes of fever and mouth ulcers.


It occurs in 1 in 1 million people in the world.


Cyclic Neutropenia is caused due to autosomal dominant inherited mutations in ELA2 gene. This is the gene which encodes the gene neutrophils elastase. The gene is released when the body attempts to fight against any infection in the body. But due to their absence, the bone marrow needs time to replenish the neutrophils supply. This neutrophils deficiency tends to occur every three weeks and lasts for three to six days.

Signs and Symptoms

The episodes of neutropenia become apparent after birth. The cycle of neutropenia usually comes after every 21 days lasting for 3 to 4 days. Following symptoms may follow after the cycle starts:

  • Oral ulcers
  • Swelling and inflammation of gums (Gingivitis)
  • Sinusitis: Respiratory tract infections like cough and cold
  • Inflammation of throat (Pharyngitis)
  • Recurrent fever
  • Abdominal pain
  • Generalized weakness and malaise

Patients suffering from cyclic neutropenia have these symptoms only during the cycle. They remain asymptomatic otherwise. It is to be noted that the above listed symptoms may improve once the puberty sets in the child.


Patients with cyclic neutropenia or suspected individuals should be genetically tested for ELANE gene.

Blood investigations like complete blood count, total leukocyte count and differential leukocyte count should be performed. The neutrophil count should be monitored twice in a month.


Conventional Treatment for Cyclic Neutropenia

A drug that stimulates the bone marrow called recombinant human granulocyte colony stimulating factor for neutrophils production (Rhg- CSF) can be given along with antibiotic therapy to control recurrent infections. Another drug neupogen (Filgrastim) has been approved for the treatment of chronic neutropenia. Genetic counseling can also be done in order to know the genetic status of the patient.

Homeopathic Treatment for Cyclic Neutropenia

A supportive and symptomatic relief can be given to patients with cyclic neutropenia. Homeopathy can help to boost the immunity and improve the general well being of the patient. A good control can be achieved in the recurrence and frequency of the infectious attacks in the patients. The intensity of the symptoms as well as time duration of the illness can be reduced which will improve the quality of life. Moreover, oral and dental care is very essential. Patients of chronic neutropenia should take care from afflicting any major or minor injuries.

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